Different individuals may respond to medication in different ways. In patients with Theophylline overdose who are at high risk for Theophylline-induced seizures, e. Accurate prediction of dose-dependency of Theophylline metabolism in patients a priori is not possible, but patients with very high initial clearance rates i.
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If only total serum Theophylline concentration is measured, this may lead to an unnecessary and potentially dangerous dose increase. Administer a single dose of oral activated charcoal.
Elderly patients are at a significantly greater risk of experiencing serious toxicity from Theophylline than younger patients due to pharmacokinetic and pharmacodynamic changes associated with aging.
Phenytoin increases Theophylline clearance by increasing microsomal enzyme activity. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants.
Induction of histone deacetylase activity to decrease inflammatory gene expression". Different rates of elimination and consequent dosage requirements have been observed among other peoples.
Check symptom Check drugs Compare drugs. Caffeine concentrations are usually undetectable in adults regardless of renal function. The dose of Theophylline must be individualized on the basis of peak serum Theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects.
The mean T max was 6. The extent of reduction in Theophylline clearance in patients with CHF appears to be directly correlated to the severity of the cardiac disease.
Before taking theophylline
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A [ citation needed ] US: Conversely, if Theophylline is being initiated in a patient who is already taking a drug that enhances Theophylline clearance e. Careful consideration of the various interacting drugs and physiologic conditions that can alter Theophylline clearance and require dosage adjustment should occur prior to initiation of Theophylline therapy, prior to increases in Theophylline dose, and during follow up see WARNINGS.
C Risk not ruled out. A trough concentration i. Fed conditions were the same as those previously cited. Treat overdose as indicated see recommendations for chronic overdosage. Theophylline is an oral bronchodilator medicine which is prescribed for people with breathing problems, such as asthma and chronic obstructive pulmonary disease COPD.