Fatigue and ankle oedema have been reported rarely. Treat all Verapamil overdoses as serious and maintain observation for at least 48 hours especially the extended-release formulationpreferably under continuous hospital care. Upgrade your browser today or install Google Chrome Frame to better experience this site.
Most adverse effects responded well to dose reduction, and only rarely did Verapamil use have to be discontinued. It is soluble in water, chloroform, and methanol. Please note that Internet Explorer version 8. Verapamil can cause loss of alertness, so driving or operating machinery while taking the medication may be out of the question. Verapamil hydrochloride is a calcium ion influx inhibitor slow-channel blocker or calcium ion antagonist available for oral administration in film-coated tablets containing 80 mg or mg of Verapamil hydrochloride.
Studies in female rats at daily dietary doses up to 5. Male and Female Fertility Main Effects: Many patients will require more than one drug to achieve blood pressure goals.
Impotence erectile dysfunction has been rarely reported and isolated cases of galactorrhoea.
Such an effect was observed in one study following the concomitant administration of Verapamil and prazosin. The dose of Verapamil must be individualized by titration. Patients receiving both drugs must be monitored carefully. Until data on possible interactions between Verapamil and disopyramide are obtained, disopyramide should not be administered within 48 hours before or 24 hours after Verapamil administration.
Because of the potential for adverse reactions in nursing infants from Verapamil, nursing should be discontinued while Verapamil is administered. An month toxicity study in rats, at a low multiple 6-fold of the maximum recommended human dose, and not the maximum tolerated dose, did not suggest a tumorigenic potential.
Date of revision of the text. Interactions between verapamil and the following medications have been reported: Its efficacy in reducing both raised systolic and diastolic blood pressure is thought to be due to this mode of action.
Author links open overlay panel Abeer F. However, 40 mg three times a day may be warranted in patients who may have an increased response to Verapamil e.
Verapamil crosses the placental barrier and can be detected in umbilical vein blood at delivery. It may be necessary to decrease the dosage of Verapamil when it is administered to patients with attenuated neuromuscular transmission. In clinical experience with 4, patients, 87 1.
A nonlinear correlation between the Verapamil dose administered and Verapamil plasma levels does exist.