Clofarabine cyclophosphamide and etoposide

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Voluntary written consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care Exclusion Criteria: Eligibility Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

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Neither patient gender, WBC count at diagnosis, nor age at treatment influenced the probability to respond to the treatment data not shown. Of particular interest is the observation that almost half the patients who achieved either CR or CRp were refractory to their most recent prior regimens. Dose calculation was based on body-surface area obtained from height and actual weight. History and physical examination, complete blood count, serum chemistry and BM aspirate were performed before starting chemotherapy.

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. January Final data collection date for primary outcome measure. Talk with your doctor and family members or friends about deciding to join a study. In view of this finding and of the possible, unknown interaction of the triple combination with intrathecal chemotherapy, none of the patients received CNS prophylaxis.

A relapse study of the BFM group. It is possible that the different dosages of drugs, the prolonged hospitalization of our patients and the aggressive policy of prophylaxis that we adopted against infections may have contributed to the absence of severe, life-threatening toxicity in our cohort.

Generally the high induction remission rate is offset by higher treatment-related mortality.

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Thank you for sharing this Blood Journal article. Blood and Marrow Transplantation Program.

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September 3, Last Update Posted: Response to treatment was assessed using morphological, cytogenetic and immunophenotyping analysis.

This scheme proved to be safe and tolerable, as none of the 25 patients enrolled in our study died due to treatment-related complications. We are updating the design of this site.

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All drugs were administered for 5 consecutive days. Department of Health and Human Services.

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Broad spectrum antibiotics were given if a patient became febrile. Christopher EhmannDavid F. This report describes the results of a multicentre study carried out in paediatric patients with either multiple relapsed or refractory ALL who received a single course of clofarabine therapy combined with cyclophosphamide and etoposide with the aim of re-inducing remission. Number of times cited: