Among many others, the following women have sustained a Fosamax femur fracture: Because of these potentially dangerous side effects, Merck recommends that patients sit upright or stand for a full 30 minutes after taking the drug and take it with a full glass of water.
Methods Study design We used a nationwide population based open registry cohort study, containing two nested case-control studies, to determine the risk of subtrochanteric and femoral shaft and hip fractures as a function of cumulative alendronate use, time, and adherence to assess long term skeletal safety and efficacy. Unfortunately, we have little solid evidence to guide us in this area.
Furthermore, realistic comorbidity adjusted number needed to treat to harm and number needed to treat scenarios suggested that use of alendronate for more than 10 years remains favourable at the femur and hip. When somebody sustains an insufficiency fracture low-trauma or NO trauma it should be considered serious and could be an emergency.
Fosamax is the oldest of these drugs and has been used the most and studied the longest. When I saw this I had them change the wording immediately on my reports and taught the tech how to ask the right questions to determine if the fracture was significant. Many doctors do not fully understand what exactly an insufficiency fracture is or that prolonged use of these medications is associated with insufficiency fractures. The research indicated that rare but serious Fosamax femur fractures are associated with long-term use.
Sensitivity analyses investigated subsequent treatment with other drugs for osteoporosis. Doctors prescribe Fosamax to prevent age-related bone damage. Hip fractures lead to hospitalization and, usually, surgery — and they often result in nursing home care. Until we know more, women taking Fosamax who have severe osteoporosis or a prior fracture should probably continue doing so indefinitely.
Dead Jaw Syndrome (Osteonecrosis)
The active ingredient in Fosamax is alendronate, and it belongs to a drug class called bisphosphonates. The researchers reported similar findings in a smaller study in ; they theorized that prolonged suppression of bone remodeling by Fosamax may have encouraged fracture-inducing microdamage to the bone. This is akin to identifying risk factors for breast cancer solely from a case comparison with women with colon cancer.
Incident outcomes were included in the analysis irrespective of current treatment status so that we could determine the association with strength of exposure dose years, present user or not, medication possession ratio MPR a proxy for compliance.
It is possible, however, to slow down this particular aging process by eating healthy food and exercising. Japanese and European health agencies found 21 more cases. Call us for help. Meanwhile, continue all the other measures that help protect and maintain bone density: RE and DP-A are joint senior authors.
Radiology abstract - Pubmed citation. Use of more than 10 dose years of alendronate was associated with a decreased risk 0.
Table 2 Comorbid conditions and comedications at time of event in two nested case-control studies.