Patients receiving these medications may require larger amounts of hyaluronidase for equivalent dispersing effect. Administer oxygen, usually 8 to 10 L per minute; lower concentrations may be appropriate for patients with chronic obstructive pulmonary disease. Maximum daily dosage is mg.
Benadryl Ampoule —sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in a 1-mL ampoule. Urinary and serum histamine levels and plasma tryptase levels drawn after onset of symptoms may assist in diagnosis. Monitor for increased CNS effects if coadministering. The author indicates that she does not have any conflicts of interest. Consider the patient's use of alcohol or illicit drugs when prescribing CNS depressant medications.
Moderate Additive CNS depression may occur if dichloralphenazone is used concomitantly with any of the sedating H1 blockers. To see the full article, log in or purchase access.
Small, single or occasional doses of diphenhydramine, when necessary, would not be expected to cause adverse effects in breast-fed infants. Patients given the combination tend to have higher metoprolol plasma concentrations and greater pharmacodynamic effects from metoprolol. Minor Although desloratadine is considered a 'non-sedating' antihistamine, dose-related sedation has been noted.
No reactions were reported as requiring medical attention. This may be of significance in the elderly and wearers of contact lenses. In addition, the risk of next-day psychomotor impairment is increased during co-administration of eszopiclone and other CNS depressants, which may decrease the ability to perform tasks requiring full mental alertness such as driving.
Sedating H1-blockers may exhibit significant anticholinergic activity, thereby interfering with the therapeutic effect of tacrine. To decrease the likelihood of an administration route error, store topical preparations separately from oral products and advise patients to do the same.
Although antihistamines should be avoided during an acute asthmatic attack, these anticholinergic effects do not preclude the use of antihistamines in all asthmatic or COPD patients, particularly if the above respiratory symptom is not a primary component of the illness. Children and Adolescents 12 years and older. The site may be gently massaged to facilitate absorption.
The elderly are more susceptible to the anticholinergic effects of drugs since there is a decline in endogenous cholinergic activity that occurs with age. Moderate COMT inhibitors, such as entacapone or tolcapone, should be given cautiously with other agents that cause CNS depression, including sedating H1-blockers, due to the possibility of additive sedation.
Dosing & Uses
J Allergy Clin Immunol. These doses can be repeated every six hours, as required.
A continuous infusion of glucagon, 1 to 5 mg per hour, may be given if required. Additive anticholinergic effects may occur.