Angina aspirinamlodipinecarvedilolmetoprololatenololMore Administration of nitroglycerin infusions through the same infusion set as blood can result in pseudoagglutination and hemolysis. As tolerance to other forms of nitroglycerin develops, the effect of sublingual nitroglycerin on exercise tolerance, although still observable, is somewhat blunted. Intravenous administration of solutions may cause fluid overloading resulting in dilution of serum electrolyte concentrations, overhydration and congested states of pulmonary edema; risk of dilutional states is inversely proportional to electrolyte concentrations of injections; risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to electrolyte concentration of injections.
Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure afterload. Safety and effectiveness in children have not been established. Amplification of the vasodilatory effects of nitroglycerin by sildenafil can result in severe hypotension.
Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy. Dilatation of the coronary arteries also occurs. Print this page Add to My Med List. When these parameters were elevated, reducing them toward normal usually caused a rise in cardiac output.
Chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence.
The diagnosis should be suspected in patients who exhibit signs of impaired oxygen delivery despite adequate cardiac output and adequate arterial pO2. This drug is available at a middle level co-pay. In industrial workers who have had long-term exposure to unknown presumably high doses of organic nitrates, tolerance clearly occurs.
Use supportive treatment in overdose; there is no specific antidote for overdose; risk of overdose can be minimized by close monitoring during treatment.
In patients with renal disease or congestive heart failure, therapy resulting in central volume expansion is not without hazard. This drug is available at a higher level co-pay.
Contact the applicable plan provider for the most current information. Clinical Pharmacology The principal pharmacological action of Nitroglycerin Injection is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Because of the problem of nitroglycerin absorption by polyvinyl chloride PVC tubing, Nitroglycerin Injection should be used with the least absorptive infusion tubing i. Some in-line intravenous filters also absorb nitroglycerin; these filters should be avoided.
The time course and dose dependence of this interaction have not been studied.
Positive evidence of human fetal risk. The organic nitrates are vasodilators, active on both arteries and veins. Serious Methemoglobinemia rare Syncope Prolonged bleeding time Exfoliative dermatitis Unstable angina Rebound hypertension Thrombocytopenia.