Baclofen therapy for chronic hiccup

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The primary outcome measure was cessation of hiccups. However, larger studies are warranted. Learn from Experienced Professionals. Neurological Deficit Scale RR: Choose courses based on your needs.

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We conducted a randomized, double-blind, placebo-controlled, 5-day clinical trial to evaluate the possible benefit of baclofen in treating persistent hiccups after stroke. With localized medical news and in-language editions. Therefore, 30 individuals were randomized into the study. Although a Cochrane systematic review found no sufficient evidence for the treatment of persistent or intractable hiccups with either pharmacologic or nonpharmacologic interventions, all four studies included in the review had focused on acupuncture, and not baclofen, or even other pharmacologic interventions [ 20 ].

In a large series of patients, we have evaluated its therapeutic position. Of these people, 34 subjects were excluded because of the following: Persistent hiccups followed by cardiorespiratory arrest. Patients were recruited between August and November Baclofen produced a long-term complete resolution 18 cases or a considerable decrease 10 cases of hiccups in 28 of the 37 patients.

Earn course certificates and optional CME. Abstract Background The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. Showing of 12 references. Episodes of hiccups often start with sudden inspiration and end with abrupt closure of the glottis.

We consider that the randomization was acceptable, and we will explore whether the window for eligibility can be extended.

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This study was a two-parallel arm, blinded, randomized controlled trial. The study has several strengths. In this study, participants were initially screened. The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups.

This low incidence of adverse effects might be attributable to the short duration of the study. Baclofen in the treatment of persistent hiccup: Compliance and follow-up were also acceptable. J Assoc Physicians India. Comparison of efficacy between the two groups. Chronic hiccup is a rare but potentially severe condition, that can be symptomatic of a variety of diseases, or idiopathic. J Neurol Neurosurg Psychiatry.

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