Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. It is prudent to use substantial caution when prescribing angiotensin II receptor antagonists in patients with a history of ACE-inhibitor induced angioedema.
If you get any side effects, talk to your doctor, pharmacist or nurse. Moderate Angiotensin II receptor antagonists ARBs may enhance the hypoglycemic effects of pramlintide by improving insulin sensitivity. Contents of the pack and other information. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Find medicines from the same company. Side effects in children are similar to those seen in adults. Perform serial ultrasound examinations to assess the intra-amniotic environment.
The volume of distribution of losartan and the active metabolite is about 34 liters and 12 liters, respectively. John's Wort, Hypericum perforatum: Pediatric dose may be administered as a tablet or suspension.
There was no significant difference in the incidence of the composite endpoint of cardiovascular morbidity and mortality. The antihypertensive effects of COZAAR were demonstrated principally in 4 placebo-controlled, 6- to week trials of dosages from 10 to mg per day in patients with baseline diastolic blood pressures of The maximal effects usually occur within the first week of therapy, although in some studies maximal effect has occurred after 3—6 weeks of treatment.
Following oral administration, losartan is well absorbed and undergoes substantial first-pass metabolism. Losartan should be used with caution patients with hyperkalemia.
Use with particular caution in hypertensive patients with high or uncontrolled blood pressure. You can also report side effects directly via the Yellow Card Scheme at www. Careful monitoring of blood pressure is suggested during coadministration.
Marketing Authorisation Holder and Manufacturer: Anaphylactic reactions have been reported. The usual recommended starting dose is 0.