Loratadine assay

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All measurements are carried out by running simultaneous blank determinations and the final titer values are subtracted from blank to get actual amount of acetous perchloric acid equivalent to LOR. The method was found to be selective, sensitive, precise and accurate for the determination of impurities and degradation products.

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Accuracy of the determination of the impurities were carried out in triplicate at 0. The flow rate is about 1 mL per minute. The percentage recoveries of the proposed method were ranged from Results and Discussion Method development In order to develop an improved suitable and robust LC method for the determination of Loratadine and its impurities and degradation products, different mobile phases and columns were employed to achieve the best separation and resolution.

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Add 2 mL of Solution A, then dilute with methanol to volume, and mix. J Anal Bioanal Tech 7: This method can be used for the routine determinations in pharmaceutical quality control laboratories. LOQ values were found to be 0.

Authors would also like to thank colleagues in separation science division of Analytical Research and Development department of Dr. System suitability parameters were measured so as to verify the system performance. Two drops of crystal violet indicator were added and the solution was titrated with standard solution of HClO 4. Chromatograph the Standard preparation, and record the peak area responses as directed for Procedure: Typical chromatogram for 0.


Loratadine is a second generation antihistamine drug closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies, which is available in the market as Claritin. University, Kukatpally, Hyderabad, A.

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This all system suitability parameters covered the system, method and column performance. Make adjustments if necessary see System Suitability under Chromatography The end point reached when the color of indicator was converted from violet to faint blue. Footnotes This article is available from: Validation of Analytical Procedure. National Center for Biotechnology InformationU. Traces of unmetabolized loratadine can be found in the urine [ 1 ].

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The LC system used for method development and method validation was Waters LC system with a diode array detector Model, quaternary gradient.