Methotrexate uses in gynecology

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Monteagudo A, Tarricone NJ, Timor-Tritsch IE, Lerner JP Successful transvaginal ultrasound-guided puncture and injection of a cervical pregnancy in a patient with simultaneous intrauterine pregnancy and a history of a previous cervical pregnancy.

American Journal of Epidemiology.

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Transvaginal ultrasonography TVUS became increasingly available in the late s, and by the mid s sensitivity and specificity were calculated at Newer agents with greater efficacy and lesser toxicity could greatly improve the care of women with this condition [ 522 ].

Abstract Methotrexate was developed in as a synthetic folic acid analogue to compete with folic acid and thus interfere with cell replication. Collaborative Review of Sterilization Working Group.

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This portion of the tube is then excised. Clinical Gynecologic Endocrinology and Infertility. Gestational Trophoblastic Neoplasia 3.

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Methotrexate has subsequently revolutionized the treatment of two pregnancy-related conditions—gestational trophoblastic neoplasia and ectopic pregnancy. Trends in ectopic pregnancy mortality in the United States: The overall success rate of medical treatment in properly selected women is nearly 90 percent [ 3,4 ].

Of leaves and butterflies: Sep 28, Author: Rheumatrex Dose Pack, Trexall Methotrexate 2.

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In addition, methotrexate has been used to treat pregnancies implanted within a uterine scar and in patients with placenta accreta. Adverse drug effects include the following:. It carries high risk of uterine perforation and in particular, significant haemorrhage, as trophoblastic tissue is highly vascular and prone to arteriovenous malformations in GTN [ 28 ].

How should I take methotrexate? Where can I get more information? Surgical treatment in these cases is often associated with increased risk of hemorrhage, often resulting in hysterectomy or oophorectomy.

Patients should be aware of the signs and symptoms associated with tubal rupture, and they should be advised to contact their physician with significantly worsening abdominal pain or tenderness, heavy vaginal bleeding, dizziness, tachycardia, palpitations, or syncope.

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The history of the diagnosis and treatment of ectopic pregnancy: Increased abdominal pain is believed to be caused by the separation of the pregnancy from the implanted site. A common etiology of abnormal uterine bleeding. History and Origins Methotrexate was one of the first drugs synthesized for a specific chemotherapeutic purpose— in situ folic acid inhibition for the treatment of acute lymphoblastic leukaemia ALL in children [ 1 ].

It is used clinically in medicine to treat a range of cancerous and noncancerous conditions. Introduction Methotrexate is an antifolate drug which inhibits cell division by interfering with DNA replication [ 1 ].