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The half-life in the patient population aged 1 to 4 month was reported to average 6. Moderate Bosentan is an inducer of cytochrome P enzymes, specifically the CYP2C9 and CYP3A4 isoenzymes, and may decrease concentrations of drugs metabolized by these enzymes including ondansetron.

Bepridil is associated with a known risk for QT prolongation and torsade de pointes TdP. Major Avoid coadministration of chloroquine with ondansetron if possible, due to the risk of QT prolongation and torsade de pointes TdP. Give the first dose 30 minutes prior to chemotherapy, with subsequent doses 4 and 8 hours after the initial dose.

There is no information on the effects of ondansetron on human fertility.

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If concomitant use cannot be avoided, obtain electrocardiograms frequently and closely monitor patients for signs and symptoms of ondansetron toxicity, including QT prolongation and cardiac arrhythmias. Serotonin syndrome is characterized by rapid development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes e. In addition, concurrent use of opioids with other drugs that modulate serotonergic function, such as ondansetron, has resulted in serotonin syndrome in some cases.

Major Caution is advised with the concomitant use of tamoxifen and ondansetron due to an increased risk of QT prolongation and torsade de pointes TdP.

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Further doses may be given every 8 hours for 1 to 5 days after completion of therapy. Ask your doctor if you have any questions. As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration. Three patients were continued on oral therapy of 8 mg PO twice daily, with decreased severity of symptoms.

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Ondansetron has also been associated with a dose-related increase in the QT interval and postmarketing reports of torsade de pointes TdP. Major Monitor electrolytes and ECGs for QT prolongation if coadministration of ondansetron with oxaliplatin is necessary; correct electrolyte abnormalities prior to administration of oxaliplatin.

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Although ondansetron is primarily metabolized by other CYP isoenzymes i. New Strategies for Improving Outcomes Emergency room management of ADHF including critical decision-making points in resuscitation for both hypertensive and hypotensive patients and a review of newer medications.

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Although there are no studies examining the effects of dronedarone in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation. Up to 3 doses of 0. For the prevention of PONV: Because of multiple neurochemical receptor sites involved during surgery, combination antiemetic therapy with drugs of different mechanisms is often necessary.

Major Ondansetron should be used cautiously and with close monitoring with disopyramide. Major If possible, avoid coadministration of amiodarone and ondansetron.

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Diagnosis and Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease This issue presents strategies and algorithms for the early use of evidence-based interventions, including appropriate use of antibiotics, bronchodilators, and corticosteroids, along with noninvasive ventilation with capnography, to minimize morbidity and mortality associated with this disease.