Electroclinical correlations with plasma and saliva levels of anticonvulsivantes in epileptic patients. The last trimester of pregnancy, perhaps because of dilutional hypoalbuminaemia.
How should I take Dilantin? In these patients with acute hepatotoxicity, Dilantin should be immediately discontinued and not readministered. This can be done by calling the toll free numberand must be done by patients themselves.
In addition, the fetal hydantoin syndrome, a pattern of abnormalities including dysmorphic skull and facial features, nail and digit hypoplasia, growth abnormalities including microcephalyand cognitive deficits has been reported among children born to epileptic women who took phenytoin alone or in combination with other antiepileptic drugs during pregnancy [see Data ].
Third, drug level monitoring is not the only monitoring required with these drugs. To view content sources and attributions, please refer to our editorial policy. Dosage programming of phenobarbital in neonatal seizures. Dilantin extended capsules and parental Dilantin are formulated with the sodium salt of phenytoin. When, in the judgment of the clinician, the need for dosage reduction, discontinuation, or substitution of alternative anticonvulsant medication arises, this should be done gradually.
In all cases of lymphadenopathy, follow-up observation for an extended period is indicated and every effort should be made to achieve seizure control using alternative antiepileptic drugs. Graphic estimation of phenytoin dose in adults and children.
Less-common uses of phenytoin include the treatment of neuropathic pain, motion sicknessmuscular dystrophyand arrhythmia. One-compartment model with zero order absorption and Michaelis-Menten elimination. The effect of carbamazepine on valproic acid disposition in adults volunteers.
Administration of phenytoin to pregnant rats, rabbits, and mice during organogenesis resulted in embryofetal death, fetal malformations, and decreased fetal growth.
Patients with unusually low levels may be noncompliant or hypermetabolizers of phenytoin.
Effects of discontinuation of phenytoin, carbamazepine and valproate on concomitant antiepileptic medication. The free acid form of phenytoin is used in Dilantin Suspension and Dilantin Infatabs. Advise patients not to discontinue use of Dilantin without consulting with their healthcare provider.
See " What is the most important information I should know about Dilantin? Pharmacokinetic optimization of anticonvulsant therapy. The following equation is useful in predicting normalized phenytoin concentrations for this kind of patients: Such changes may or may not result from a full review of the article, so the two dates may not always agree.