Retrieved 29 June Clinical pharmacology of Cozaar.
EXP is times more potent in blocking AT 1 receptors than losartan. Reduction in blood pressure occurs independently of the status of the renin-angiotensin system.
Captopril Rentiapril Zofenopril Dicarboxylate-containing: It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback. The terminal elimination half lives of losartan and EXP are about 1.
Losartan is a selective, competitive angiotensin II receptor type 1 AT 1 antagonist, reducing the end organ responses to angiotensin II. Losartan should not be taken by people who are diabetic and taking aliskiren.
Uses authors parameter link CS1 maint: Losartan administration results in a decrease in total peripheral resistance afterload and cardiac venous return preload.
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This page was last edited on 1 Novemberat Losartan is generally marketed as the basic potassium salt of the aromatized negatively charged tetrazolecalled "losartan potassium. Peak plasma concentrations of losartan and EXP occur about one hour and three to four hours, respectively, after an oral dose.
As with all angiotensin II type 1 receptor AT 1 antagonists, losartan is indicated for the treatment of hypertension.
Losartan and other angiotensin-receptor antagonists exhibit fetal toxicity and should be avoided during pregnancy, particularly in the second and third trimesters. Losartan is a uricosuric. The maximal effects on blood pressure usually occur within 3—6 weeks of starting losartan.
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In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug. Uses authors parameter CS1 maint: Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most patients due to both efficacy [ citation needed ] and costan angiotensin II receptor antagonist such as losartan is recommended as first-line treatment in patients under the age of 55 who cannot tolerate an ACE inhibitor.
Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites.