Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. Clinical pharmacology of Cozaar.
Uses for Losartan Potassium
Therapy with angiotensin II receptor antagonists. Peak plasma concentrations of losartan and its active metabolite attained 1 and 3—4 hours, respectively, following oral administration. J Clin Pharm Ther. Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in the hypertension study LIFE: Recently it has been suggested that higher doses of AIIAs may reduce proteinuria further by a non-haemodynamic action [ 5 ], raising the question of whether their therapeutic renoprotective dose might not be considerably higher than the conventional antihypertensive dose.
Preserving renal function in adults with hypertension and diabetes: Retrieved January 6, Manufacturer recommends initial dosage of 25 mg once daily in adults with a history of hepatic impairment.
Laboratory tests revealed moderate elevations in serum bilirubin 9. Effect of antihypertensive therapy on the kidney in patients with diabetes: No initial dosage adjustments recommended by manufacturer for adults with renal impairment, including those undergoing hemodialysis. The only significant differences with time were in measures of proteinuria and of daytime arterial BP systolic, diastolic and mean.
The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. The radiation effective dose equivalent of the combined measurement was 0. Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrollingindividuals. The angiotensin II antagonist AIIA losartan has now been shown to have a similar effect [ 5 ] and, given their superior side effect profile, the increasing use of AIIAs in proteinuric diseases can be expected.
Effects of candesartan on mortality and morbidity in patients with chronic heart failure: Losartansold under the trade name Cozaar among others, is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure hypertension.
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Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Diovan valsartan tablets prescribing information. Angiotensin-receptor blockade and risk of cancer: Uricosuric action of losartan via the inhibition of urate transporter 1 URAT 1 in hypertensive patients.