Few data are available regarding newer drugs in the treatment of primary disease. This was during week for the male rats and week for the female rats. Acyclovir Tablets USP mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo " on one side and plain on the other side.
This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Precipitation of acyclovir in renal tubules may occur when the solubility 2. The pharmacokinetics of acyclovir after oral administration have been evaluated in healthy volunteers and in immunocompromised patients with herpes simplex or varicella-zoster virus infection. In general, the pharmacokinetics of acyclovir in pediatric patients is similar to that of adults. For the treatment of initial and recurrent mucosal and cutaneous herpes simplex HSV-1 and HSV-2 in immunocompromised patients.
However, certain patient groups, such as the severely immunocompromised especially bone marrow transplant recipients and those undergoing chronic suppressive regimens have been identified as being most frequently associated with the emergence of resistant herpes simplex strains, which may or may not accompany a poor response to the drug.
Patients are instructed to consult with their physician if they experience severe or troublesome adverse reactions, they become pregnant or intend to become pregnant, they intend to breastfeed while taking orally administered acyclovir, or they have any other questions. The duration of pain after healing was longer in patients 65 and over.
Patients have ingested up to 20 g acyclovir on a single occasion, with no unexpected adverse effects. Prolonged continuous versus intermittent oral acyclovir treatment in normal adults with frequently recurring genital herpes simplex virus infection. Zovirax Eye Ointment Updated Oct This website also contains material copyrighted by 3rd parties. Oral acyclovir and herpes labialis: The diagnosis of genital HSV infection may be made clinically, but laboratory confirmation is recommended in patients presenting with primary or suspected recurrent infection.
Email Alerts Don't miss a single issue. Virasorb Cold Sore Cream. Prolonged acyclovir treatment of highly immunocompromised patients with acquired immunodeficiency syndrome and severe VZV may lead to the appearance of resistant virus. Green J, Kocsis A. Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The decrease in bioavailability is a function of the dose and not the dosage form. Accidental, repeated overdoses of oral acyclovir over several days have been associated with gastrointestinal effects such as nausea and vomiting and neurological effects headache and confusion. They are supplied as follows:.
Acyclovir tablet is intended for oral ingestion only.
Acyclovir gave no positive responses in any of these systems.