The serum concentration of Methotrexate can be increased when it is combined with Evening primrose oil. The therapeutic efficacy of Bumetanide can be decreased when used in combination with Methotrexate.
Hepatic histology was not examined in these short-term studies. Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. Manifestations of this stroke-like encephalopathy may include confusion, hemiparesis, transient blindness, seizures and coma.
See package insert for routes of administration. The 1 gram vial contains approximately 7 mEq sodium. The risk or severity of adverse effects can be increased when Tacrolimus is combined with Methotrexate.
Its main function is the regulation of the colloid Laboratory studies demonstrate that it may be displaced from plasma albumin by various compounds including sulfonamides, salicylates, tetracyclines, chloramphenicol, and phenytoin.
Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA pre In the treatment of patients with osteosarcoma, caution must be exercised if high-dose methotrexate is administered in combination with a potentially nephrotoxic chemotherapeutic agent e.
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates sodium-independent multispecific organic anion transport. The most frequently reported adverse reactions include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Unexpectedly severe and sometimes fatal marrow suppression, aplastic anemia, and GI toxicity have been reported with coadministration of NSAIDs. The therapeutic efficacy of Furosemide can be decreased when used in combination with Methotrexate.
An accurate incidence rate has not been determined; the rate of progression and reversibility of lesions is not known.
Skin reactions Severe and occasionally fatal skin reactions have been reported. The serum concentration of Methotrexate can be increased when it is combined with Choline magnesium trisalicylate. The serum concentration of Methotrexate can be increased when it is combined with Mycophenolic acid.
Several guidelines on this subject have been published. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Epub Apr 7. General Function Organic anion transmembrane transporter activity Specific Function May act as an inducible transporter in the biliary and intestinal excretion of organic anions. The serum concentration of Methotrexate can be increased when it is combined with Procaine benzylpenicillin.
The serum concentration of Methotrexate can be increased when it is combined with Imidazole salicylate. A variety of combination chemotherapy regimens have been used for both induction and maintenance therapy in acute lymphoblastic leukemia.
Use caution when administering high-dose methotrexate to patients receiving proton pump inhibitor PPI therapy. It should be appreciated, however, that the doses used in rheumatoid arthritis 7.
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.